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Which Nodes Should You Anoint?

When choosing which Notable to Anoint in Path of Exile 2, consider:

Is it too far from my path to reach normally?
Does it provide an effect I can't find elsewhere?
Does this Notable fix a build weakness? (Mana, Life, Resistances, etc.)
Is the Liquid Emotion cost worth the benefit?
Offence-focused builds typically benefit most from Fangs of the Viper, Divine Judgement, and Disciple of the Slaughter.
Defence-heavy or HC players gravitate toward Constitution and Prismatic Skin.
Casters often choose Arcane Dominion or Righteous Decree.
Summoners always consider Gravepact.

If you're short on Liquid Emotions or Path of Exile 2 Currency, you can also buy POE2 Items to complete your optimal Anoint setup without grinding endlessly.

Final Thoughts

Anointing is one of the most powerful build-customisation tools in Path of Exile 2, allowing players to bypass the limitations of the sprawling passive tree and pick up high-impact Notables from anywhere. Whether you need more damage, extra survivability, or build-defining utility, the right Anoint can completely transform your character.

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